Day: October 24, 2022

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Taconic Biosciences Launches First and Only Super Immunodeficient Mouse Models Lacking Residual Murine Fc Gamma Receptors, for Improved Antibody Therapy Assessment

FcResolv™ NOG Models Provide Greater Clarity and More Translatable Data

RENSSELAER, N.Y., Oct. 24, 2022 (GLOBE NEWSWIRE) — Taconic Biosciences, a global leader in providing drug discovery animal model solutions, has launched the FcResolv™ NOG portfolio, the first and only super immunodeficient mouse models lacking residual murine Fc gamma receptors (FcγRs) known to confound results in antibody-based therapy studies.

Murine FcγRs can cause false positives or false negatives, leading to incorrect conclusions and derail drug discovery. FcResolv NOG models knock out these receptors for greater clarity in antibody-based drug studies, affording investigators greater confidence and more translatable data with fewer studies and fewer animals. With applicability in oncology, immuno-oncology, and autoimmune disease, FcResolv NOG models are suitable for engrafting a wide range of human cells and tissues, including simultaneous human tumor engraftment and immune system humanization.

“Antibody-based therapies represent one of the fastest-growing classes of drugs, creating a pressing need for better preclinical tools to assess therapeutics such as monoclonal antibodies, antibody-drug conjugates, and bispecific antibodies,” said Dr. Michael Seiler, vice president of commercial products at Taconic. “Taconic’s FcResolv NOG portfolio enables researchers to evaluate drug candidates like these on their own merits, free of interference from residual murine Fc gamma receptor activity.”

FcResolv NOG models eliminate the false negatives that occur when an antibody-based therapeutic’s Fc domain interacts with murine FcγRs as well as the false positives that result when FcγRs trigger residual murine immune activity. They also eliminate costly deconvolution steps otherwise needed to distinguish true drug efficacy from off-target effects mediated through the mouse immune system. With more reliable answers, researchers can target their drug discovery investments more strategically and effectively.

The FcResolv NOG model portfolio is based on the super immunodeficient CIEA NOG mouse®. The portfolio currently includes two models:

  • FcResolv NOG, for tumor xenografts using cell lines or patient-derived tumors, engraftment of other normal or pathological human cells and tissues, and immune system humanization studies
  • FcResolv hIL-15 NOG, which supports engraftment of human NK cells and is suitable for efficacy studies on antibody-based therapeutics with an antibody-dependent cellular cytotoxicity (ADCC) mechanism of action

To learn more about the FcResolv NOG portfolio, visit www.Taconic.com/fcresolv. Or call 1-888-TACONIC (888-822-6642) in the US, +45 70 23 04 05 in Europe, or email info@taconic.com.

About Taconic Biosciences, Inc.

Taconic Biosciences is a fully licensed, global leader in genetically engineered rodent models and services. Founded in 1952, Taconic provides the best animal solutions so that customers can acquire, custom-generate, breed, precondition, test, and distribute valuable research models worldwide. Specialists in genetically engineered mouse and rat models, microbiome, immuno-oncology mouse models, and integrated model design and breeding services, Taconic operates service laboratories and breeding facilities in the U.S. and Europe, maintains distributor relationships in Asia and has global shipping capabilities to provide animal models almost anywhere in the world.

Media Contact:

Louise Baskin, Senior Director New Product Pipeline

303-432-2495

Louise.Baskin@taconic.com

GlobeNewswire Distribution ID 8670208

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Taconic Biosciences lance le premier et le seul modèle de souris super immunodéficientes dépourvus de récepteurs Fc Gamma murins résiduels, pour une évaluation améliorée de la thérapie par anticorps

Les modèles FcResolv™ NOG offrent une plus grande clarté et des données plus traduisibles

RENSSELAER, New York, 24 oct. 2022 (GLOBE NEWSWIRE) — Taconic Biosciences, un leader mondial dans la fourniture de solutions de modèles animaux pour la découverte de médicaments, a lancé le portefeuille FcResolv™ NOG, les premiers et seuls modèles de souris super immunodéficientes dépourvus de récepteurs Fc Gamma murins résiduels (FcyRs) connus pour fausser les résultats dans les études thérapeutiques à base d’anticorps.

Les FcyRs murins peuvent provoquer de faux positifs ou de faux négatifs, ce qui conduit à des conclusions erronées et fait dérailler la découverte de médicaments. Les modèles FcResolv NOG éliminent ces récepteurs pour une plus grande clarté dans les études médicamenteuses à base d’anticorps, offrant aux chercheurs une plus grande confiance et des données plus traduisibles avec moins d’études et moins d’animaux. Avec une applicabilité en oncologie, en immuno-oncologie et en maladie auto-immune, les modèles FcResolv NOG sont adaptés à la greffe d’un large éventail de cellules et tissus humains, y compris la greffe de tumeurs humaines simultanée et l’humanisation du système immunitaire.

« Les thérapies à base d’anticorps représentent l’une des classes de médicaments à la croissance la plus rapide, créant un besoin urgent de meilleurs outils précliniques pour évaluer des traitements tels que les anticorps monoclonaux, les conjugués anticorps-médicaments et les anticorps bispécifiques », a déclaré le Dr Michael Seiler, vice-président des produits commerciaux chez Taconic. « Le portefeuille de récepteurs FcResolv NOG de Taconic permet aux chercheurs d’évaluer des médicaments candidats tels que ceux-ci selon leurs propres mérites, sans interférence de l’activité résiduelle du récepteur Fc Gamma murin. »

Les modèles FcResolv NOG éliminent les faux négatifs qui se produisent lorsqu’un domaine Fc thérapeutique à base d’anticorps interagit avec les FcyRs murins, ainsi que les faux positifs qui en résultent lorsque les FcyRs déclenchent une activité immunitaire murine résiduelle. Ils éliminent également les étapes de déconvolution coûteuses nécessaires pour distinguer une véritable efficacité médicamenteuse des effets hors cible induits par le système immunitaire de la souris. Grâce à des réponses plus fiables, les chercheurs peuvent cibler leurs investissements dans la découverte de médicaments de manière plus stratégique et plus efficace.

Le portefeuille de modèles NOG FcResolv est basé sur la souris® NOG CIEA super immunodéficiente. Le portefeuille comprend actuellement deux modèles :

  • FcResolv NOG, pour les xérogreffes tumorales utilisant des lignées cellulaires ou des tumeurs dérivées des patients, la greffe d’autres cellules et tissus humains normaux ou pathologiques, et les études d’humanisation du système immunitaire
  • FcResolv hIL-15 NOG, qui supporte la greffe des cellules NK humaines et convient pour des études d’efficacité sur les thérapies à base d’anticorps avec un mécanisme d’action de cytotoxicité cellulaire dépendant des anticorps (ADCC)

Pour en savoir plus sur le portefeuille de FcResolv NOG, rendez-vous sur www.Taconic.com/fcresolv. Vous pouvez également appeler le 1-888-TACONIC (888-822-6642) aux États-Unis, le +45 70 23 04 05 en Europe, ou envoyer un e-mail à l’adresse info@taconic.com.

À propos de Taconic Biosciences, Inc.

Taconic Biosciences est un leader mondial pleinement agréé dans les modèles et les services de rongeurs génétiquement modifiés. Fondée en 1952, Taconic offre les meilleures solutions animales afin que les clients puissent acquérir, générer d’une manière personnalisée, élever, pré-conditionner, tester et distribuer des modèles de recherche précieux dans le monde entier. Spécialiste des modèles de souris et de rats génétiquement modifiés, du microbiome, des modèles de souris pour l’immuno-oncologie et des services de conception de modèles intégrés et d’élevage, Taconic exploite des laboratoires de services et des établissements d’élevage aux États-Unis et en Europe, entretient des relations de distribution en Asie et dispose de capacités d’expédition mondiales pour fournir des modèles animaux presque partout dans le monde.

Contact auprès des médias :

Louise Baskin, directrice principale du nouveau Pipeline de produits

303-432-2495

Louise.Baskin@taconic.com

GlobeNewswire Distribution ID 8670426


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Taconic Biosciences Lança Primeiro e Único Modelo de Camundongo Super Imunodeficiente Sem Receptores Gama Fc Murino Residuais, para Avaliação de Terapia de Anticorpo Aprimorada

Modelos FcResolv™ NOG proporcionam dados mais claros e mais traduzíveis

RENSSELAER, NY, Oct. 24, 2022 (GLOBE NEWSWIRE) — A Taconic Biosciences, líder global no fornecimento de soluções de modelo animal para descoberta de medicamentos, lançou o portfólio FcResolv™ NOG, o primeiro e único modelo de camundongo superimunodeficiente sem receptores Fc gama murinos residuais (FcγRs) conhecidos por confundir os resultados nos estudos de terapia com base em anticorpos.

Os FcγRs murinos podem causar falsos positivos ou falsos negativos, levando a conclusões incorretas e afetar a descoberta de medicamentos. Os modelos FcResolv NOG eliminam esses receptores para maior clareza nos estudos de medicamentos com base em anticorpos, proporcionando aos investigadores maior confiança e dados mais traduzíveis, com menos estudos e menos animais. Com aplicabilidade em oncologia, imuno-oncologia e doença autoimune, os modelos FcResolv NOG são adequados para enxertos de uma ampla gama de células e tecidos humanos, incluindo enxerto simultâneo de tumor humano e humanização do sistema imunológico.

“As terapias com base em anticorpos são uma das classes de medicamentos de crescimento mais rápido, criando uma necessidade urgente de melhores ferramentas pré-clínicas para a avaliação terapêutica, como de anticorpos monoclonais, conjugados anticorpo-droga e anticorpos biespecíficos”, disse o Dr. Michael Seiler, vice-presidente de produtos comerciais da Taconic. “O portfólio FcResolv NOG da Taconic permite que pesquisadores avaliem candidatos a medicamentos como esses por si próprios, sem interferência da atividade residual do receptor Fc gama murino.”

Os modelos FcResolv NOG eliminam os falsos negativos que ocorrem quando o domínio Fc de um terapêutico com base em anticorpos interage com os FcγRs murinos, bem como os falsos positivos que resultam quando os FcγRs desencadeiam atividade imune murina residual. Eles também eliminam as etapas dispendiosas de desconvolução que normalmente são necessárias para distinguir a verdadeira eficácia do medicamento dos efeitos fora do alvo mediados pelo sistema imunológico do camundongo. Com respostas mais confiáveis, os pesquisadores podem direcionar seus investimentos em descoberta de medicamentos de forma mais estratégica e eficaz.

O portfólio do modelo FcResolv NOG tem como base o CIEA NOG mouse® superimunodeficiente. Atualmente, o portfólio inclui dois modelos:

  • FcResolv NOG, para xenoenxertos de tumores com linhagens celulares ou tumores derivados de pacientes, enxerto de outras células e tecidos humanos normais ou patológicos, e estudos de humanização do sistema imunológico
  • FcResolv hIL-15 NOG, que aceita enxertos de células NK humanas e é adequado para estudos de eficácia em terapêutica com base em anticorpos com um mecanismo de ação de citotoxicidade celular dependente de anticorpos (ADCC)

Para mais informação sobre o portfólio FcResolv NOG, visite www.Taconic.com/fcresolv. Ou ligue para 1-888-TACONIC (888-822-6642) nos EUA, +45 70 23 04 05 na Europa, ou envie email para info@taconic.com.

Sobre a Taconic Biosciences, Inc.

A Taconic Biosciences é uma líder global totalmente licenciada em serviços e modelos geneticamente modificados. Fundada em 1952, a Taconic oferece as melhores soluções/modelos de pesquisas em murinos, para que os clientes possam adquirir, customizar, criar, pré-condicionar, testar e distribuir valiosos modelos de pesquisa em todo o mundo. Especializada em modelos de camundongos e de ratos geneticamente projetados, microbioma, modelos de camundongos imuno-oncologia, e serviços de design e criação de modelos integrados, a Taconic opera laboratórios de serviços e instalações de criação nos EUA e na Europa, mantém relações com distribuidores na Ásia , e tem capacidades de entrega em nível global para oferecer modelos em quase qualquer lugar no mundo.

Contato com a Mídia:

Louise Baskin, Diretora Sênior de Pipeline de Novos Produtos

303-432-2495

Louise.Baskin@taconic.com

GlobeNewswire Distribution ID 8670426

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Lisa Cole Joins Cellebrite as Chief Marketing Officer

Lisa Cole

Lisa Cole

PETAH TIKVA, Israel and TYSONS CORNER, Va., Oct. 24, 2022 (GLOBE NEWSWIRE) — Cellebrite DI Ltd. (Nasdaq: CLBT), a global leader in Digital Intelligence (DI) solutions for the public and private sectors, today announced Lisa Cole as Chief Marketing Officer (CMO).

As CMO for the leading global Digital Intelligence provider, Lisa will be responsible for the company’s overall marketing strategy and execution, which includes brand, public relations, product marketing, demand generation, and marketing operations.

“With the recent surge in crime and digital sophistication of criminals at a time of strained budgets and staff, protecting and serving citizens is harder than ever before,” said Lisa Cole, Chief Marketing Officer at Cellebrite. “Cellebrite empowers the world’s leading agencies and enterprises to modernize their investigative workflows and culture to close the widening public safety gap. I am honored to be part of Cellebrite’s next phase of growth and look forward to driving greater adoption of Digital Intelligence solutions to make the world a safer place.”

Prior to joining Cellebrite, Lisa was the Vice President of Corporate Marketing at FARO. Before FARO, she was the Chief Marketing Officer at Huron. Her transformative work for both companies improved performance and resulted in three prestigious honors: the 2022 Forrester Return on Integration (ROI) Award, SiriusDecisions’ 2018 ROI Award, and Demand Gen Report’s 2018 B2B Innovator Award. Lisa holds a BS in Marketing Management from Western Governors University.

“As Cellebrite continues to grow and evolve, it is critical that the company adjusts and pivots as needed to drive growth and success,” said Yossi Carmil, Chief Executive Officer of Cellebrite. “Lisa will help strategically elevate our marketing efforts to drive sales and further develop the company’s leadership position in the Digital Intelligence marketplace.”

About Cellebrite

Cellebrite’s (Nasdaq: CLBT) mission is to enable its customers to protect and save lives, accelerate justice, and preserve privacy in communities around the world. We are a global leader in Digital Intelligence solutions for the public and private sectors, empowering organizations in mastering the complexities of legally sanctioned digital investigations by streamlining intelligence processes. Trusted by thousands of leading agencies and companies worldwide, Cellebrite’s Digital Intelligence platform and solutions transform how customers collect, review, analyze and manage data in legally sanctioned investigations. To learn more visit us at www.cellebrite.com, https://investors.cellebrite.com, or follow us on Twitter at @Cellebrite_UFED.

Cellebrite Media
Victor Cooper
Public Relations and Corporate Communications Director
Victor.Cooper@cellebrite.com
+1 404.804.5910

Investors
Investor Relations
investors@cellebrite.com

A photo accompanying this announcement is available at https://www.globenewswire.com/NewsRoom/AttachmentNg/362ab0ad-4b03-4e9c-a6fd-ee18abbd8cb5


Copyright © 2022 GlobeNewswire, Inc.

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Ethiopia Peace Talks Set to Start in South Africa


Delegations to African Union-mediated peace talks on the war in Ethiopia’s Tigray region meet in South Africa today despite a renewed offensive that saw federal forces re-take a few towns from Tigrayan forces.

The Ethiopian government put out a statement saying it viewed the talks as “an opportunity to peacefully resolve the conflict.”

For their part, the leadership of the Tigray People’s Liberation Front, or the TPLF, also confirmed their attendance, with a member of the central committee, Kindeya Gebrehiwot, tweeting that the delegation had arrived in South Africa Sunday.

The Tigray delegation is being led by one of the region’s top generals, Tsadkan Gebretensae, spokesman Getachew Reda, an official familiar with the talks told Reuters.

The Tigrayans arrived on a U.S. military aircraft, accompanied by the U.S. special envoy to the Horn of Africa, Mike Hammer, the official told Reuters.

Officials from host country South Africa were remaining mum on the much-anticipated negotiations, and their exact location is unclear. It is also unclear whether media will be addressed at their conclusion, or a statement released.

Clayson Monyela, a spokesman for South Africa’s Department of International Relations and Cooperation, told VOA the department had no authority to speak on the talks and referred any questions to the African Union, which is organizing them. A spokesperson for the AU could not immediately be reached.

The talks come as fighting on the ground intensified, with the Ethiopian government saying they had “continued taking control of major urban centers in the past few days.”


U.N. Secretary-General Antonio Guterres warned last week that the situation was “spiraling out of control,” while World Health Organization chief Tedros Adhanom Ghebreyesus, himself a Tigrayan, warned of the possibility of genocide.

Thousands of people have been killed and millions displaced since the conflict broke out in late 2020.

The U.S. has expressed hope that the peace talks in South Africa will lead to a cessation of hostilities. Secretary of State Antony Blinken said Sunday he had spoken to South African counterpart Naledi Pandor “on how to make the peace talks successful.”

From the Vatican over the weekend, Pope Francis tweeted: “I follow the persistent situation of conflict in Ethiopia with trepidation. May the efforts of the parties for dialogue lead to a genuine path of reconciliation.”

Source: Voice of America

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Ethiopia’s Warring Parties Convene for Tigray Peace Talks in South Africa

Peace talks between Ethiopian government officials and representatives from the leadership of the Tigray People’s Liberation Front are due to begin Monday in South Africa. Just ahead of the talks, Ethiopian federal forces took two more towns in Tigray previously under Tigrayan forces’ control.

Humanitarian sources told VOA that federal Ethiopian troops and allied Eritrean forces have taken control of the towns of Axum and Adwa, the latest in a series of setbacks for forces led by the rebel Tigray People’s Liberation Front.

Tigrayan forces retreated from Adwa after suffering heavy losses, one of the sources said.

Last Tuesday, pro-federal government forces captured Shire in northwest Tigray, a major urban hub that hosts hundreds of thousands of people displaced by two years of fighting. The government has vowed to take control of the Tigray region’s airports and federal institutions.

The news comes as negotiators for the federal government and the Tigray forces arrive in South Africa for peace talks convened by the African Union.

Diplomats have urged the parties to agree to a cease-fire, with U.S. Secretary of State Anthony Blinken sounding the alarm Friday over “reports of significant loss of life, destruction, indiscriminate bombardment, and human rights abuses” in northern Ethiopia.

More than half a million people have been displaced in northwest Tigray alone since the fighting resumed on August 24, with tens of thousands more uprooted in the neighboring Amhara region.

Source: Voice of America

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MEC David Maynier wishes Western Cape matric candidates the very best for the exams

#Classof2022: Cheating is not an option!

Note to editors: attached please find a soundbite from MEC Maynier, and the commitment agreement signed by candidates. Photos of the MEC’s visit to Vista Nova High School are available here:

https://drive.google.com/drive/folders/1wtC8kCFWcblzEIWsK-i0C3HUr8czn-wX?usp=sharing(link is external)

Last week, I visited Vista Nova High School in Pinelands to wish matric candidates the very best for the exams, and witness the signing of their matric Commitment Agreements for the National Senior Certificate (NSC) exams.

Every matric candidate, along with a parent or guardian, is required to sign the Commitment Agreement, which clearly outlines what behaviour is not acceptable during the exams, and what can happen if the rules are not followed.

Among other rules, cellphones and notes are not permitted in the exam room. The agreement also outlines the responsibility of the candidate to report any information or rumour regarding exam irregularities.

I urge every candidate to take the agreement very, very seriously. They have signed the formal agreement, and cannot later claim to have not known they could not have notes in the exam room, or have forgotten that they had a cellphone with them.

While we did not have any mass cheating incidents during the 2021 exams, 9 learners were found in possession of crib notes, and a further 14 brought a cellphone into the exam room.

The consequences of such actions are serious: if found guilty, a candidate could be disqualified from the exam, and even be barred from writing up to three subsequent examinations.

Criminal prosecution could be instituted should it be found that the candidate is involved in the leakage of any examination question paper.

The severe consequences outweigh any perceived benefit of cheating. It is simply not worth it. Our matrics are old enough to understand the importance of following the rules, and parents also have a responsibility to ensure that their children understand what behaviour is not allowed during their exam period.

Load shedding

Tomorrow, 11 030 learners will start their matric exams with the Computer Applications Technology (CAT) practical. 927 learners will complete their Information Technology (IT) practical exam on Wednesday.

We hope that Eskom will be able to safeguard the exam times from load shedding, but we nonetheless have clear protocols in place in case of power failures during the practical exams and will monitor the situation closely.

We wish our matrics all the best for their practical exams this week, and look forward to celebrating their results in January.

Source: Government of South Africa